Vital Choice - Wild Seafood & Organics
Click to Call
Food, Health, and Eco-news
Strawberries Seen to Enhance Long-Term Memory
11/06/2006

Got flavonoids? Study shows how colorful fruits and veggies help preserve long-term brain health

by Craig Weatherby


Researchers in the US and Japan have published the results of a mouse study with implications for the benefits of Americans' favorite berry (Maher P et al 2006).


As Lead author Pamela Maher, Ph.D. of the Salk Institute said, "…the holy grail of CNS [central nervous system] research in the pharmaceutical industry is the identification of a safe, orally active drug that activates memory-associated pathways and enhances memory."


And her team may have found a good candidate, if not the grail itself. The US-Japan team found that fisetina flavonoid-class polyphenol antioxidant found in strawberries and other fruits and vegetablesstimulates signaling pathways that enhance long-term memory.


Dr. Maher discovered the beneficial effects of fisetin earlier, while screening a number of flavonoids for their ability to protect brain cells in a test-tube experiment that simulated the effects of Alzheimer's and other degenerative brain diseases.


She found that many flavonoids perform several key functions:

  • Protect brain cells from dying
  • Promote new connections between nerve cells
  • Promotes memory formation.

The pan-Pacific team found that fisetin also stimulated key processes in the hippocampus: a part of the brain that plays a key role in creating and storing new memories.


(For any neuroscientists in the audience, fisetin activated the ERK signaling pathway, stimulated long-term potentiation, and induced phosphorylation of the cAMP response element-binding protein in hippocampal tissues from the rats.)


They also tested fisetin's ability to help mice remember different objects, and found that the animals given a dose of fisetin recalled objects more quickly and easily.


In fact, the extract improved their performance about as effectively as a new drug called rolipram, which enhances memory by making brain synapses more resistant to damage caused by accumulation of the beta-amyloid protein plaques characteristic of Alzheimer's.


Fisetin is also found in tomatoes, onions, oranges, apples, peaches, grapes, kiwifruit and persimmons. (Interestingly, while the memory-enhancing supplements derived from the leaves of Gingko biloba trees are rich in other flavonoids, they do not contain fisetin.)


Fortunately, fisetin is not the only brain-benefiting flavonoid, since it would take about 10 pounds of strawberries a day to equal the dose given the mice!


Instead, the idea is to fill your diet with berries and a range of colorful, flavonoid-filled foods and beverages: a perfectly pleasurable prospect.



Sources

  • Maher P, Akaishi T, Abe K. Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16568-73. Epub 2006 Oct 18.
  • Bourtchuladze R, Frenguelli B, Blendy J, Cioffi D, Schutz G, Silva AJ. Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell. 1994 Oct 7;79(1):59-68.

WHAT OUR CUSTOMERS ARE SAYING:
quote-icon
I would not buy my fish from anywhere but Vital Choice…I’m so happy to have a source for great tasting, healthy fish.
quote-icon
WHAT HEALTH & NUTRITION EXPERTS ARE SAYING:
quote-icon
Vitalchoice.com is my favorite source for wild Alaskan salmon, sablefish, sardines, and other fish rich in omega-3s... I can't tell you how many messages I get from people thanking me for recommending Vital Choice.
quote-icon
WHAT OUR CUSTOMERS ARE SAYING:
quote-icon
Simply put Vital Choice offers the best seafood and related products available. We have always recommended Vital Choice to clients, friends, and family. As health practitioners we value the sustainable practices and trust this company implicitly!
quote-icon
WHAT THE MEDIA IS SAYING:

quote-icon We’ve done the work for you to find the healthiest meat products on the market. quote-icon

WHAT HEALTH & NUTRITION EXPERTS ARE SAYING:
quote-icon
Unlike anything you've seen from the grocery store…I recommend Vital Choice—my personal favorite for delicious, fresh, healthy, and completely safe canned tuna and salmon.
quote-icon
WHAT THE MEDIA IS SAYING:
quote-icon
Vital Box captures the fresh-caught quality of succulent, sustainably harvested Alaskan salmon and northwest Pacific seafood by cleaning and flash-freezing it within hours of harvest.
quote-icon
WHAT HEALTH & NUTRITION EXPERTS ARE SAYING:
quote-icon
I love the stellar quality of Vital Choice salmon! I've been recommending Vital Choice Seafood for many years now.
quote-icon
WHAT OUR CUSTOMERS ARE SAYING:
quote-icon
Vital choice has never disappointed. Love every item I get... since eating your food, my hair, skin, and energy revitalized from clean fish and meats… it’s ALL great. Never a problem with the food arriving in great condition.
quote-icon
WHAT THE MEDIA IS SAYING:

quote-icon The Best Places To Buy Seafood Online, Including Fresh And Frozen Fish quote-icon 

Find out what others are saying about Vital Choice
Trustpilot
Ad